Fractal regional myocardial blood flows pattern according to metabolism, not vascular anatomy

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Fractal regional myocardial blood flows pattern according to metabolism, not vascular anatomy.

Regional myocardial blood flows are markedly heterogeneous. Fractal analysis shows strong near-neighbor correlation. In experiments to distinguish control by vascular anatomy vs. local vasomotion, coronary flows were increased in open-chest dogs by stimulating myocardial metabolism (catecholamines + atropine) with and without adenosine. During control states mean left ventricular (LV) myocardia...

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CALL FOR PAPERS Quantitative Analyses of Coronary Vascular and Cardiac Mechanics in Health and Disease Fractal regional myocardial blood flows pattern according to metabolism, not vascular anatomy

Yipintsoi T, Kroll K, Bassingthwaighte JB. Fractal regional myocardial blood flows pattern according to metabolism, not vascular anatomy. Am J Physiol Heart Circ Physiol 310: H351–H364, 2016. First published November 20, 2015; doi:10.1152/ajpheart.00632.2015.—Regional myocardial blood flows are markedly heterogeneous. Fractal analysis shows strong near-neighbor correlation. In experiments to di...

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Fractal nature of regional myocardial blood flow heterogeneity.

Spatial variation in regional flows within the heart, skeletal muscle, and in other organs, and temporal variations in local arteriolar velocities and flows is measurable even with low resolution techniques. A problem in the assessment of the importance of such variations has been that the observed variance increases with increasing spatial or temporal resolution in the measurements. This resol...

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Regional Myocardial Blood Flow

Do oxygen-derived free radicals, generated at the time of reperfusion, lethally injure viable, previously ischemic myocardium, damage vascular endothelium, and impair recovery of postischemic contractile function? To address these issues, 23 anesthetized open-chest dogs underwent 2 hours of left anterior descending coronary artery occlusion followed by 4 hours of reperfusion. Immediately prior ...

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Regional Myocardial Blood Flow

nary artery disease has provided an intense stimulus for expansion of our present knowledge of the coronary circulation. In the experimental animal laboratory, the electromagnetic flowmeter has proved to be an excellent tool by which one can study dynamic aspects of the coronary circulation. A flowmeter is clearly unsuitable for human investigation; therefore, the search for a simple method of ...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology

سال: 2016

ISSN: 0363-6135,1522-1539

DOI: 10.1152/ajpheart.00632.2015